Small Molecule-Based Pattern Recognition To Classify RNA Structure

Pattern Recognition System to Classify Student’s Emotion using Forehead Wrinkles

Facial expressions play an essential role in communications in social interactions with other human beings which deliver rich information about their emotions. Here, we propose an efficient method for identifying the expressions of the students to recognize their comprehension from the facial expressions in static images containing the frontal view of the human face. Our goal is to categorize t...

Electron paramagnetic resonance dynamic signatures of TAR RNA-small molecule complexes provide insight into RNA structure and recognition.

Electron paramagnetic resonance (EPR) spectroscopy was utilized to investigate the correlation between RNA structure and RNA internal dynamics in complexes of HIV-1 TAR RNA with small molecules. TAR RNAs containing single nitroxide spin-labels in the 2'-position of U23, U25, U38, or U40 were incubated with compounds known to inhibit TAR-Tat complex formation. The combined changes in nucleotide ...

A novel pattern recognition algorithm to classify membrane protein unfolding pathways with high-throughput single-molecule force spectroscopy

MOTIVATION Misfolding of membrane proteins plays an important role in many human diseases such as retinitis pigmentosa, hereditary deafness and diabetes insipidus. Little is known about membrane proteins as there are only very few high-resolution structures. Single-molecule force spectroscopy is a novel technique, which measures the force necessary to pull a protein out of a membrane. Such forc...

A structure based pattern recognition on antibodies

Motivations Protein-protein interactions are deeply involved in the antibody::antigen recognition process. Crystallographic data offer evidence of conformational changes between apo and holo forms of antibodies complexed with antigens. Nevertheless, the dynamical aspects of intermolecular relationships still remain a challenging issue. Extensive molecular dynamics (MD) simulations offer the sui...

RNA Isolation (Small RNA Extraction). Fatemeh Mehrpooyan*